Taui, A high-resolution metabolic imaging biomarker for myocardium
نویسندگان
چکیده
منابع مشابه
Taui, A high-resolution metabolic imaging biomarker for myocardium
Background Contrast-enhanced H2O T1-weighted cardiovascular MRI is usually interpreted using tracer paradigms; e.g., the extra-/intravascular contrast agent (CA) partition coefficient. However, the signal molecule is water, not CA. Consequently, the myocardial extracellular volume fraction (ECV) is underestimated in proportion to its magnitude. Even more importantly, intercompartmental water ex...
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Background The equilibrium cellular water efflux rate constant [kio; mean water lifetime inverse] from contrast agent [CA]enhanced MRI measures on-going cellular Na,K-ATPase activity [turnover]. Good literature [4 different labs] agreement shows substantial kio decreases in myocardial ischemia, hypertension, or infarct regions (Table). The 3 methods used differ in extracellular ("outside”) CAo ...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Magnetic Resonance
سال: 2014
ISSN: 1532-429X
DOI: 10.1186/1532-429x-16-s1-o111